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This sequence activates TGF-activated kinase 1, leading to the phosphorylation of the inhibitor of κB kinase, degradation of IκB, release of NF-κB and its translocation into the nucleus to regulate the expression of various inflammatory responses (77)

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The nervous system rapidly regulates organ interactions through pathways such as the vagus nerve, 17,18 whereas the endocrine system transmits information across multiple organs via hormonal signals such as insulin and cortisol